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Articles by Tain Luquez
Cell-type signatures of Alzheimer’s disease shared across population groups
Abstract Genomic studies at single-cell resolution have identified several cell types associated with clinical and pathological traits in Alzheimer’s disease1,2,3,4,5,6,7,8,9, but have not examined associations that are shared across populations.
Single-cell transcriptomics of human brain disorders
Abstract Brain disease is ultimately a disease of its constituent cells, and single-cell genomics has recently begun to illuminate the cellular pathologies underlying human brain disorders. In this review, we synthesize the key biological insights from recent single-cell studies of post-mortem human brain tissue across a range of neurological and psychiatric conditions.
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
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Keywords clusterin risk variants human iPSC cells astrocyte-microglia crosstalk Alzheimer’s disease astrocyte reactivity synapse density complement APOE TAU Get full text access Log in, subscribe or purchase for full access. References 1. Bertrand, P. ∙ Poirier, J. ∙ Oda, T. ... Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease Brain Res. Mol. Brain Res. 1995; 33:174-178 2. Lidström, A.M. ∙ Bogdanovic, N. ∙ Hesse, C. ...
By Alexandra M. Lish, Elyssa F.L. Grogan, Courtney Benoit, Richard Pearse, Sarah Heuer, Tain Luquez, Gwendolyn A. Orme, Paige C. Galle, Giedre Milinkeviciute, Kim Green, Kellianne D. Alexander, Seeley B. Fancher, Andrew Stern, Masashi Fujita, David Bennett, Nicholas T. Seyfried, Vilas Menon, Tracy L. Young-Pearse
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Cell Press
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Annotation Comparison Explorer (ACE): connecting brain cell types across studies of health and Alzheimer's Disease
Abstract Single-cell multiomic technologies have allowed unprecedented access to gene profiles of individual cells across species and organ systems, including >1000 papers focused on brain cell types alone. The Allen Institute has created foundational atlases characterizing mammalian brain cell types in the adult mouse brain and the neocortex of aged humans with and without Alzheimer's disease (AD).
Relation of CMV and brain atrophy to trajectories of immunosenescence in diverse populations
Abstract Immunosenescence (ISC), the aging of the immune system, has largely been studied in populations of European descent. Here, circulating immune cell cytometric data from African-American, Hispanic, and non-Hispanic White participants were generated. Known and novel age effects were identified using either a meta-analysis approach or a parallel genetic approach.
Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease - Genome Medicine
References Selkoe DJ. The molecular pathology of Alzheimer’s disease. Neuron. 1991;6(4):487–98. Article CAS PubMed Google Scholar Perl DP. Neuropathology of Alzheimer’s disease. Mt Sinai J Med. 2010;77(1):32–42. Article PubMed PubMed Central Google Scholar Braak H, et al. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol. 2006;112(4):389–404. Article PubMed PubMed Central Google Scholar Kantarci K.
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