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Takayoshi Otsuka on Muck Rack

Takayoshi Otsuka

As seen in: MDPI, PNAS, BioRxiv
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Articles

Extracellular disposal of nuclear waste by APP: a protective mechanism impaired in Alzheimer's disease

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By Takayoshi Otsuka, Yuka Nakamura, Akiko Sakai, Godfried Dougnon
| BioRxiv
Abstract Although the amyloid beta (Abeta) hypothesis (1) has long been central to Alzheimer's disease (AD) research, effective therapeutic strategies remain elusive (2,3). Here we re-evaluate the functions of amyloid precursor protein (APP) and reveal its critical function in protecting against nuclear impairment-induced cell death and inflammation (4,5).
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Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders

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By Takayoshi Otsuka, Hideaki Matsui
| MDPI
Abstract : Neurodegenerative disorders are characterized by the progressive loss of neuronal structure or function, resulting in memory loss and movement disorders. Although the detailed pathogenic mechanism has not been elucidated, it is thought to be related to the loss of mitochondrial function in the process of aging. Animal models that mimic the pathology of a disease are essential for understanding human diseases.
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Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits

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By Paulos Y Mengsteab, Takayoshi Otsuka, Aneesah McClinton, Nikoo Saveh Shemshaki
| PNAS Verified
Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits Paulos Y. Mengsteab, Takayoshi Otsuka, Aneesah McClinton, Nikoo Saveh Shemshaki, Shiv Shah, Ho-Man Kan, Elifho Obopilwe, Anthony T. Vella, Lakshmi S. Nair, Cato T. Laurencin Proceedings of the National Academy of Sciences Nov 2020, 202012347; DOI: 10.1073/pnas.2012347117
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