Takwon Yoo

Keywords fumarate succination parkin Parkinson's disease PINK1 VDAC1/2 ANT1 Get full text access Log in, subscribe or purchase for full access. References 1. Jetto, C.T. ∙ Nambiar, A. ∙ Manjithaya, R. Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns Front. Cell Dev. Biol. 2022; 10, 837337 2. Wang, Q.X. ∙ Xue, H.Y. ∙ Yue, Y.D. ... Role of mitophagy in the neurodegenerative diseases and its pharmacological advances: A review Front. Mol. Neurosci. 2022; 15, 1014251 3. Ajoolabady, A.

eLife assessment The study has identified a cell type in muscle that is characterized as an adipogenic progenitor cell that is capable of promoting regeneration through the action of BDNF, a prominent growth factor regulated by GDNF in Schwann cells. These results represent an important cellular explanation for nerve regeneration. The revised analysis is solid but the work remains incomplete due to a lack of evidence that BDNF is produced during the process through the action of GDNF.

Abstract Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal progenitors that can contribute to muscle tissue homeostasis and regeneration, as well as postnatal maturation and lifelong maintenance of the neuromuscular system. Recently, traumatic injury to the peripheral nerve was shown to activate FAPs, suggesting that FAPs can respond to nerve injury.