Talyn Chu

In contrast with the classical dogma that the pathways generating either memory or ‘exhausted’ T cells are strictly segregated, data now identify a clonally distinct hybrid memory T cell subpopulation with an exhausted phenotype. T cell differentiation correlates with the type of infection that triggers the immune response. If the infection resolves rapidly, a fraction of activated T cells go on to form different types of circulating and resident memory T cells.

Talyn Chu Talyn Chu Affiliations Division of Animal Physiology and Immunology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany Search for articles by this author Dietmar Zehn 2 Author Footnotes 2 Present address: Division of Animal Physiology and Immunology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany Dietmar Zehn Correspondence Corresponding author Footnotes 2 Present address: Division of Animal...

Talyn Chu, Minjian Ni, Chunmo Chen, Shreeram Akilesh and Jessica A. Hamerman J Immunol May 1, 2019, 202 (9) 2529-2534; DOI: https://doi.org/10.4049/jimmunol.1801267 Key Points TLR7-driven lupus-like disease is ameliorated in the absence of BCAP. BCAP promotes TLR7/9-induced IFNα, but not IL-6, in pDC. BCAP associates with DOCK2 and promotes CpG DNA-induced Rac1 and IKKα activation.