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Tamara Timic Stamenic on Muck Rack

Tamara Timic Stamenic

As seen in: MDPI
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Articles

Role of Thalamic CaV3.1 T-Channels in Fear Conditioning

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By Tamara Timic Stamenic, Srdjan M. Joksimovic, Brier Fine-Raquet, Vasilije P. Tadic
| MDPI
1. Introduction Contextual fear conditioning (CFC) is a form of Pavlovian learning in which an association is made between non-threatening environmental stimuli and painful, dangerous, or threatening stimulation [1,2]. Studies of Pavlovian fear conditioning and extinction in rodents and humans have suggested that a neural circuit including the hippocampus, amygdala, and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behavior [3].
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The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile

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By Francesca Manzella, Tamara Timic Stamenic, Simon Feseha, Damon Wallace
| bjanaesthesia.org
Abstract Background The mechanisms underlying the role of T-type calcium channels (T-channels) in thalamocortical excitability and oscillations in vivo during neurosteroid-induced hypnosis are largely unknown.
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