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Phage-Based Vaccine Platforms for Typhoid Fever: A Transformative Approach to Global Health and Antimicrobial Resistance

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By Nnaemeka Emmanuel Nnadi, Roderick Slavcev, Tambe David Tipah
| Preprints.org
Hybrid phage vaccines integrate both display and DNA delivery mechanisms to combine structural antigen exposure and genetic antigen expression within a single platform [58]. These dual-action systems have demonstrated enhanced immune potency, balancing humoral and cellular responses. In this model, surface antigens provide immediate B-cell activation, while encoded antigens enable prolonged antigen presentation through endogenous expression. For pathogens like S.
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