Tanaji T. Talele

Keywords PARP enzymes DNA damage detection DNA damage PARylation PARPi PARP1 PARP2 deuterium exchange mass spectrometry Get full text access Log in, subscribe or purchase for full access. References 1. Pandey, N. ∙ Black, B.E. Rapid detection and signaling of DNA damage by PARP-1 Trends Biochem. Sci. 2021; 46:744-757 2. Ray Chaudhuri, A. ∙ Nussenzweig, A. The multifaceted roles of PARP1 in DNA repair and chromatin remodelling Nat. Rev. Mol. Cell Biol. 2017; 18:610-621 3. Satoh, M.S. ∙ Lindahl, T.

Abstract PARP1 and PARP2 recognize DNA breaks immediately upon their formation, generate a burst of local PARylation to signal their location, and are co-targeted by all current FDA-approved forms of PARP inhibitors (PARPi) used in the cancer clinic. Recent evidence indicates that the same PARPi molecules impact PARP2 differently from PARP1, raising the possibility that allosteric activation may also differ.