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Taneisha Sinclair

As seen in: Nature, Science Magazine, Molecular Cancer Research
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Articles by Taneisha Sinclair

Exploiting an epigenetic resistance mechanism to PI3-kinase inhibition in leukemic stem cells

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By Shira G. Glushakow-Smith, Imit Kaur, Simone Sidoli, Shayda Hemmati, Ellen Angeles, Taneisha Sinclair, Samarpana Chakraborty, Kristina Ames, Swathi-Rao Narayanagari, Mark Soto, Melissa Tracy, Seiya Kitamura, Linde A. Miles, Ulrich Steidl, Aditi Shastri, Kira Gritsman, Aaliyah Battle, Rotila Hyka, Jayaram Vankudoth
| Nature Verified
Abstract Acquired non-genetic resistance mechanisms to existing therapies contribute to poor outcomes for acute myeloid leukemia (AML) patients, and the inability to target leukemic stem cells (LSCs) can lead to relapse. To overcome these challenges, we tested whether LSCs have dependencies on PI3- kinase (PI3K). We found that LSCs are susceptible to isoform-selective targeting of PI3K and are particularly dependent on the p110 alpha isoform of PI3K.
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Abstract IA18: The PI3K isoforms in myeloid leukemia and hematopoietic stem cells

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By Boris Bartholdy, Shayda Hemmati, Taneisha Sinclair, Rachel Okabe
| Molecular Cancer Research Verified
Oral Presentations - Invited Abstracts Shayda Hemmati, Taneisha Sinclair, Meng Tong, Boris Bartholdy, Rachel Okabe, Kristina Ames, Leanne Ostrodka, Tamanna Haque, Imit Kaur, Anupriya Agarwal, Jean Zhao, Thomas Roberts and Kira Gritsman DOI: 10.1158/1557-3125.PI3K-mTOR18-IA18 Published October 2020 Abstracts: AACR Special Conference on Targeting PI3K/mTOR Signaling; November 30-December 8, 2018; Boston, MA Abstract The Class IA PI3 kinase isoforms (p110α, β, and δ) transduce many growth factor...
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