Tannu Suwal on Muck Rack

Tannu Suwal

As seen in: Cell Press
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Articles

Abstract B17: A C19MC-LIN28A-MYCN oncogenic circuit driven by hijacked super-enhancers is a distinct therapeutic vulnerability in ETMRs-a lethal brain tumor | Cancer Research

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By Iqra Mumal, Patrick Sin-Chan, Tannu Suwal, Irtisha Singh
| cancerres.aacrjournals.org
Poster Presentations - Proffered Abstracts Iqra Mumal, Patrick Sin-Chan, Tannu Suwal, Irtisha Singh, Xiao-Nan Li, Charles Lin, Stephen Mack, Jeremy Rich and Annie Huang DOI: 10.1158/1538-7445.PEDCA19-B17 Published July 2020 Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada Abstract Embryonal tumors with multilayered rosettes (ETMRs) are distinctly challenging brain tumors of infants and very young children, with...
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A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

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By Patrick Sin-Chan, Iqra Mumal, Ben Ho, Tannu Suwal
| Cell Press Verified
Highlights • C19MC alterations and chr2 gains comprise the most frequent genetic events in ETMRs • C19MC-TTYH1 gene fusion and MYCN DNA interactions create super-enhancers • Super-enhancers and multiple feedback loops fortify a C19MC-LIN28A-MYCN circuitry • BET domain inhibitors abrogate C19MC-LIN28A-MYCN circuit to induce ETMR cell death Summary Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA...
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