Tasia D Kellogg on Muck Rack

Tasia D Kellogg

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Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine

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By Simona Ceglia, Benedikt Mortzfeld, Abigail L. Zeamer, Tasia D Kellogg
| biorxiv.org
Abstract Metabolic byproducts of the intestinal microbiota are crucial in maintaining host immune tone and shaping inter-species ecological dynamics. Among these metabolites, succinate is a driver of tuft cell (TC) differentiation and consequent type 2 immunity-dependent protection against invading parasites in the small intestine. Succinate is also a growth enhancer of the nosocomial pathogen Clostridioides difficile in the large intestine.
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