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ArticleOnline nowOpen access 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA 4Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy 5Department of Pathology, University of Massachusetts Chan...
Abstract Metabolic byproducts of the intestinal microbiota are crucial in maintaining host immune tone and shaping inter-species ecological dynamics. Among these metabolites, succinate is a driver of tuft cell (TC) differentiation and consequent type 2 immunity-dependent protection against invading parasites in the small intestine. Succinate is also a growth enhancer of the nosocomial pathogen Clostridioides difficile in the large intestine.
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