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Tatsunari Kondoh on Muck Rack

Tatsunari Kondoh

As seen in: Cell Press
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Articles

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

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By Tatsunari Kondoh, Manabu Igarashi, Junki Maruyama, Yoshihiro Takadate
| Cell Press Verified
Highlights • Some bat cell lines show differential susceptibilities to Ebola and Marburg viruses • Distinctive amino acid sequences exist in the filovirus receptor of some bats • Receptor heterogeneity in bat species controls their susceptibility to filoviruses • Receptor preference is important for differential filovirus tropism to bat cells Summary Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV).
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Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor

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By Tatsunari Kondoh, Rashid Manzoor, Naganori Nao, Junki Maruyama
| PLOS
It has been proposed that some non-retroviral RNA virus genes are integrated into vertebrate genomes. Endogenous filovirus-like elements (EFLs) have been discovered in some mammalian genomes. However, their potential roles in ebolavirus infection are unclear. A filovirus VP35-like element (mlEFL35) is found in the little brown bat (Myotis lucifugus) genome. Putative mlEFL35-derived protein (mlEFL35p) contains nearly full-length amino acid sequences corresponding to ebolavirus VP35.
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