Tatu J.K. Haataja on Muck Rack

Tatu J.K. Haataja

As seen in: Cell Press
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Articles

Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia

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By Romain Capoulade, Simon Lecointe, Tatu J.K. Haataja, Maairt Hellman
| Cell Press Verified
Abstract Mitral valve diseases affect approximately 3% of the population and are the most common reasons for valvular surgery because no drug-based treatments exist. Inheritable genetic mutations have now been established as the cause of mitral valve insufficiency, and four different missense mutations in the filamin A gene ( FLNA) have been found in patients suffering from non-syndromic mitral valve dysplasia (MVD).
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