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Identification of residue inversions in large phylogenies of duplicated proteins

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By Stefano Pascarelli, Paola Laurino, Okinawa Inst, Tech. Graduate Univ
| biorxiv.org
Abstract Connecting protein sequence to function is becoming increasingly relevant since high-throughput sequencing studies accumulate large amounts of genomic data. Protein database annotation helps to bridge this gap; however, it is fundamental to understand the mechanisms underlying functional inheritance and divergence. If the homology relationship between proteins is known, can we determine whether the function diverged?
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