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Tengjin Huang on Muck Rack

Tengjin Huang

As seen in: Cell Press
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Articles

Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation

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By Yuwei Zhu, Wenbo Gao, Jianlin Zheng, Ye Bai, Xinyu Tian, Tengjin Huang, Zebin Lu, De Dong, Anqi Zhang, Changyou Guo, Zhiwei Huang
| Cell Press Verified
Keywords butyrophilin family BTN2A1 BTN3A1 BTN3A2 BTN3A3 phosphoantigen γδ TCR Introduction T cells are categorized into αβ T cells and γδ T cells based on their surface T cell receptors (TCRs), of which Vγ9Vδ2 T cells are the most abundant subset of human circulating γδ T cells.1,2 Vγ9Vδ2 T cells play a crucial role in immune responses to microbial infections and cellular tumorigenesis by generating cytotoxic and cytokine responses and regulating the phagocytosis of target cells.3,4 While...
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