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As seen in: Cell Press
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Articles

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

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By Anthony R.P. Verkerke, Zachary H. Taxin, Christopher Auger, Tenshi College
| Cell Press Verified
Highlights • BCAA is a key nitrogen source for synthesizing non-essential amino acids and GSH • Mitochondrial BCAA import via MBC is required for BCAA-derived metabolite synthesis • Reduced synthesis of BCAA-derived metabolites in BAT results in insulin resistance • Obesity impairs BCAA-nitrogen flux and BCAA-derived metabolite synthesis in BAT Summary Brown adipose tissue (BAT) is best known for thermogenesis.
Open in Who Shared Issue with article?

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

|
By Anthony R.P. Verkerke, Zachary H. Taxin, Christopher Auger, Tenshi College
| Cell Press Verified
Highlights • BCAA is a key nitrogen source for synthesizing non-essential amino acids and GSH • Mitochondrial BCAA import via MBC is required for BCAA-derived metabolite synthesis • Reduced synthesis of BCAA-derived metabolites in BAT results in insulin resistance • Obesity impairs BCAA-nitrogen flux and BCAA-derived metabolite synthesis in BAT Summary Brown adipose tissue (BAT) is best known for thermogenesis.
Open in Who Shared Issue with article?
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