Video Publish date: April 17, 2020 CGRP receptor agonists to treat migraine don’t boost stroke risk, but they could worsen stroke outcomes, according to a new animal study. “It turns out that these drugs make the blood vessels of the brain dysfunctional, such that the collateral channels that bring in blood to the region that is having the stroke are impaired,” explains the study’s lead author, Cenk Ayata, MD, associate professor of neurology and radiology at Harvard Medical School, Boston.