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thanh nguyen

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Articles

Nuclear Enlargement as a Histological Hallmark of Skeletal Muscle Aging, Revealed by Deep Learning-Driven Analysis and Validated in Inflammatory Myopathies

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By thanh nguyen, Junhyeon Park, Gia Minh Hoang
| Wiley Online Library Verified
1 Introduction Aging in skeletal muscle is characterized by progressive structural and functional decline, clinically manifesting as sarcopenia, reduced mobility, and increased frailty, significantly affecting quality of life among the elderly (Dao et al. 2020; Siparsky et al. 2014).
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Epidermal necrolysis sequelae: A cohort study on prevalence and risk factors

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By thanh nguyen, Thomas Bettuzzi, Karim Zaghbib
| Wiley Online Library Verified
Why was the study undertaken? Epidermal necrolysis (EN), including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), is a rare but severe drug-induced disease. Long-term complications remain poorly described. This study aimed to determine how frequent and severe sequelae are, identify associated risk factors and assess their social and professional impact in a large real-world cohort of EN patients. What does this study add?
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Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

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By thanh nguyen, Yeon-Ju Kim, Jihye Im
| Wiley Online Library Verified
1 Introduction Cancer immunotherapy seeks to induce durable adaptive immune responses for effective cancer treatment and prevention. A critical step in eliciting tumor-specific immunity is the effective delivery of tumor antigens to antigen-presenting cells (APCs), particularly dendritic cells (DCs) [1]. DCs internalize and process tumor antigens and present them on both major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules.
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