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Thatcher Zinabu Akele on Muck Rack

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High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro

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By Sofie Jansen, Thibault Vantieghem, Thatcher Zinabu Akele
| preprints.org
Submitted: 24 February 2026 You are already at the latest version Background and objectives: The PWWP domain of lens epithelium-derived growth factor p75 (LEDGF/p75) mediates chromatin engagement through recognition of histone H3 lysine 36 di- and trimethylation (H3K36me2/3) and nucleosomal DNA. LEDGF/p75 plays a role in multiple human diseases. In particular, its interaction with HIV-1 integrase enables viral genome integration.
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