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Thiam-Seng Ng on Muck Rack

Thiam-Seng Ng

As seen in: Nature, PLOS, PNAS, Science Magazine
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Articles

Dynamic structures of dengue virus serotype 2 secreted NS1 and their interactions with heparan sulfate

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By Qunfei Zhou, Thiam-Seng Ng, Victor A. Kostyuchenko, Guntur Fibriansah, Shee-Mei Lok, G. Suthershinii
| Nature Verified
Abstract Dengue secreted non-structural protein 1 (sNS1) contributes to the vascular permeability symptom of severe dengue hemorrhagic fever. Previous flavivirus sNS1 structures suggest that they predominantly exist as loose tetramers. Here, we report two stable tetramer structures (3.1–3.6 Å) together with loose tetramers. Formation of the stable tetramers involves a dramatic rearrangement of their N-terminal regions compared to the loose tetramers.
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Ultrapotent human antibodies lock E protein dimers central region of diverse DENV3 morphological variants - Nature Communications

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By Guntur Fibriansah, Thiam-Seng Ng, Xin-Ni Lim, Lee Ching Ng
| Nature Verified
Abstract Dengue virus (DENV) consists of four serotypes (DENV1-4). Current vaccines induce differing levels of immune response against the four serotypes, that might prime recipients to develop severe disease in subsequent infections. Several DENV tetravalent vaccine clinical trials suggested an increased incidence in severe DENV3 cases, suggesting a need to develop DENV3 therapeutics.
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Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika Virus

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By Derek L. Carbaugh, Bo Shu, Thiam-Seng Ng, PLOS Pathogens, Cameron Adams
| PLOS
G9E neutralizes ZIKV before and after attachment to the cell surface We next performed studies to define the mechanism of G9E mediated neutralization of ZIKV. In the mature virus, the E protein remains flat on the surface of the virion, burying the fusion loop within the head-to-tail E homodimer.
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