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Articles by Thilo Hackert
Autophagy and intratumoral bacteria abundance influence the prognosis of patients with pancreatic carcinoma
Abstract The biological and clinical significance of the intratumoral microbiota in pancreatic ductal adenocarcinoma (PDAC) remains poorly defined.
Individualized Cardiac Index–Guided Hemodynamic Therapy in High-Risk Patients Undergoing Elective Major Abdominal Surgery : The PELICAN Randomized Clinical Trial
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Individualized Cardiac Index–Guided Hemodynamic Therapy in High-Risk Patients Undergoing Elective Major Abdominal Surgery: The PELICAN Randomized Clinical Trial Supplement 1. Trial protocol version 1.2 Supplement 2. Trial protocol version 1.3 Supplement 3. Trial protocol version 1.4 Supplement 4. Trial protocol version 1.5 Supplement 5. Statistical analysis plan Supplement 6. eFigure 1. Preoperative Resting Cardiac Index eFigure 2.
By Bernd Saugel, Agnes S. Meidert, Christian S Meyhoff, Eske K. Aasvang, Alina Bergholz, Kristen K. Thomsen, Christian J. Zollner, Joseph Esser, Patrick Scheiermann, Nicolai Bang Foss, Jonathan Olsen, Christine Gaik, Sebastian Roth, Julian Schröder, Marc Vives, Michael Eichlseder, Thomas Renné, Eik Vettorazzi, Antonia Zapf, Karim Kouz, Moritz Flick, Linda Grüßer, Jan Larmann, Anders Karlsen, Rasmus Müller, Karin Graeser, Abdellatif El-Ahmadi, Øivind Jans, Morten Bundgaard, Troels Munch, Mette Dam, Josefine U Melchiorsen, René M'Pembele, Vlad Bucur, Theresa Tenge, Roland Dahlem, Margit Fisch, Gillis Greiwe, Thilo Hackert, Phillip Hoppe, Linda Habash Krause, Parisa Moll-Khosrawi, Felix Nickel, Anna Nießen, Susanne Reuter, Barbara Schmalfeldt, Leonie Schulte-Uentrop, Benjamin Vojnar, Florian Brandes, Sebastian Niedermaier, Elena C Berg, Robert Bischoff, Alexander Burges, Friederike Hagemann, Sven Mahner, Juliane Reichenbach, Fabian Trillsch, Ulrich Wirth, Jens M. Werner, Bernhard W. Renz, Joachim Andrassy, Markus O. Guba, Íñigo Rubio, Pablo Montero Verified, Jan Beneš, Jan Zatloukal, Abdelkader Serir, Eike Schwartze, Stephan Berthold, Melanie Borrmann, Anja Laska, Line Malmer Madsen, Anders H. Welling, Adam Klimovic, Sebastian Goldmann, Henrike Hedrich, Wiam Khader, Laima Balasova, Volker Huge, Louise B. Kiel, Tobias L. Wulff, Mikael R. Henriksen, Marlene Søgaard, Melkorka Nørgaard, Mia L. Jepsen, Jakob Højlund, Line Stendell, Ulrik Ieppsen, Till L. Christiansen, Paula Bartholomäus, Marlene Zollner, Thomas Boessner-Weiss, Moritz Bünsch, Fynn Meyer, Kaja Marie Wulschläger, Fabian Zambiasi, Moritz Steinhaus, Carla Nau, Silke Olsson, Marie-Luise Franz, Tilo Koch, Saskia Haberl, Max Kult, Anna Trebo, Bernhard Zwißler, Phillip Groene, Ludwig Lamm, Hanno Nieß, Carmen Sala, Rafael Moncada, Kristina Sikulova
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JAMA: Journal of the American Medical Association
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More is not always better: higher lymph node yield is not associated with improved survival in stage I–III colorectal cancer
Abstract Background: Colorectal cancer (CRC) is among the most prevalent malignancies worldwide and remains the second leading cause of cancer-related death. Curative treatment approaches rely on R0 resection with adequate regional lymphadenectomy. Current international guidelines recommend a lymph node yield (LNY) of at least 12 lymph nodes to ensure accurate pathological staging and to guide decisions regarding adjuvant therapy.
New implications from long-term outcomes of perioperative therapy in resectable pancreatic cancer - British Journal of Cancer
Abstract The biggest impact on increasing survival for pancreatic cancer has come about by combining surgical resection with systemic chemotherapy. This groundbreaking paradigm has come under increasing scrutiny relating to the choice of adding chemoradiotherapy to chemotherapy versus chemotherapy alone, neoadjuvant versus adjuvant therapy and the optimal regimens.
Development of a hypoxia-responsive macrophage prognostic model using single-cell and bulk RNA sequencing in pancreatic cancer
Loading metrics Open Access Peer-reviewed Research Article Citation: Ge H, Wolters-Eisfeld G, Hackert T, Li Y, Güngör C (2025) Development of a hypoxia-responsive macrophage prognostic model using single-cell and bulk RNA sequencing in pancreatic cancer. PLoS One 20(5): e0322618. https://doi.org/10.1371/journal.pone.0322618 Editor: Surinder K.
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development - Nature Communications
Abstract KRAS-dependent acinar-to-ductal metaplasia (ADM) is a fundamental step in the development of pancreatic ductal adenocarcinoma (PDAC), but the involvement of cell death pathways remains unclear. Here, we show that key regulators of programmed cell death (PCD) become upregulated during KRAS-driven ADM, thereby priming transdifferentiated cells to death.
Surgical training simulation modalities in minimally invasive surgery: How to achieve evidence-based curricula by translational research
Introduction Surgical training was for a long time mainly conducted through exposition of the trainee to procedures in the operating theatre, following the Halstedian apprenticeship model of “see one, do one, teach one” [1].
Successful doxycycline treatment of lymphatic fistulas: Report of five cases and review of the literature
Abstract Externe IDs PubMed 16683147 Schlagworte Doxycycline, Lymphatic fistula, Postoperative
Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer - Nature Reviews Gastroenterology & Hepatology
Abstract Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases with extensive vascular involvement, which can be classified as either borderline resectable pancreatic cancer or locally advanced pancreatic cancer.
JCM | Free Full-Text | Characteristics and Outcome Analysis for Intensive Care Patients Undergoing Decompressive Laparotomy for Abdominal Compartment Syndrome: Impact of Extracorporeal Membrane Oxygenation Support
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC - Nature Cancer
Abstract Neoadjuvant chemotherapy can improve the survival of individuals with borderline and unresectable pancreatic ductal adenocarcinoma; however, heterogeneous responses to chemotherapy remain a significant clinical challenge. Here, we performed RNA sequencing (n = 97) and multiplexed immunofluorescence (n = 122) on chemo-naive and postchemotherapy (post-CTX) resected patient samples (chemoradiotherapy excluded) to define the impact of neoadjuvant chemotherapy.
Enormously dilated pancreatic duct
http://orcid.org/0000-0003-2117-9137Ronald Koschny1, Matthias Lang2, Thilo Hackert2 1 Department of Gastroenterology, University of Heidelberg, Heidelberg, Germany 2 Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany Correspondence to Dr Ronald Koschny, Department of Gastroenterology, University of Heidelberg, 69120 Heidelberg, Germany; Ronald.Koschny{at}med.uni-heidelberg.de Statistics from Altmetric.com Request Permissions If you...
Survival benefit of resection surgery for pancreatic ductal adenocarcinoma with liver metastases: a propensity score-matched SEER database analysis
Thilo Hackert Thilo Hackert Affiliations Heidelberg University Hospital, Department of General- Visceral and Transplantation Surgery, Heidelberg, Germany Search for articles by this author Thomas Pausch Thomas Pausch Affiliations Heidelberg University Hospital, Department of General- Visceral and Transplantation Surgery, Heidelberg, Germany Search for articles by this author Xinchun Liu Jishu Wei Yi Miao Pascal Probst Pascal Probst Affiliations Heidelberg University Hospital-, Department of...
Enormously dilated pancreatic duct
Editor’s quiz: GI snapshot Enormously dilated pancreatic duct http://orcid.org/0000-0003-2117-9137Ronald Koschny1, Matthias Lang2, Thilo Hackert2 1Department of Gastroenterology, University of Heidelberg, Heidelberg, Germany 2Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany Correspondence to Dr Ronald Koschny, Department of Gastroenterology, University of Heidelberg, 69120 Heidelberg, Germany;...
Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery
Felix C. F. Schmitt1Email authorView ORCID ID profile, Thorsten Brenner1, Florian Uhle1, Svenja Loesch1, Thilo Hackert2, Alexis Ulrich2, Stefan Hofer3, Alexander H. Dalpke4, 5, 6, Markus A. Weigand1 and Sébastien Boutin4, 5 BMC Microbiology201919:42 https://doi.org/10.1186/s12866-019-1399-5 © The Author(s).
Targeting metabolism in pancreatic cancer
Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial
Mucinous Cystic Neoplasms of the Pancreas
[Skip to Content Landing] Invited Commentary January 2017 JAMA Surg. 2017;152(1):26. doi:10.1001/jamasurg.2016.3596 Original Investigation Preoperative Risk Factors and Pancreatic Mucinous Cystic Neoplasms Lauren M. Postlewait, MD; Cecilia G. Ethun, MD; Mia R. McInnis, BA; Nipun Merchant, MD; Alexander Parikh, MD; Kamran Idrees, MD; Chelsea A. Isom, MD; William Hawkins, MD; Ryan C. Fields, MD; Matthew Strand, MD; Sharon M. Weber, MD; Clifford S. Cho, MD; Ahmed Salem, MD; Robert C. G.
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