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Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia
Seda Seren, Lohann Derian, Irem Keleş, Antoine Guillon, Adam Lesner, Loïc Gonzalez, Thomas Baranek, Mustapha Si-Tahar, Sylvain Marchand-Adam, Dieter E.
Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia
Seda Seren, Lohann Derian, Irem Keleş, Antoine Guillon, Adam Lesner, Loïc Gonzalez, Thomas Baranek, Mustapha Si-Tahar, Sylvain Marchand-Adam, Dieter E. Jenne, Christophe Paget, Youenn Jouan, Brice Korkmaz European Respiratory Journal 2021; DOI: 10.1183/13993003.03755-2020 Abstract COVID-19 ARDS is associated with release of biologically active neutrophil elastase-related proteinases to the airways and blood at a comparable level to non-COVID ARDS.
High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision
Highlights • Unbiased scRNA-seq on thymic iNKT reveals discrete subsets in iNKT1 and iNKT2 • Transcriptomically defined iNKT2 cells comprise precursors to iNKT1 and iNKT17 • Most of thymic iNKT subsets seem to have the potential to egress the thymus • The transcription cofactor FHL2 controls specification of the iNKT1 effector fate Summary CD1d-restricted invariant Natural Killer T (iNKT) cells represent a unique class of T lymphocytes endowed with potent regulatory and effector immune...
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