Thomas Barba

1 Introduction Kidney graft allocation relies on a combination of clinical, immunological, geographical, and demographic criteria, designed to balance the principles of utility and equity [1]. Among these determinants, immunological compatibility between donors and recipients plays a pivotal role, as it directly influences both graft outcomes and access to transplantation [2].

Abstract T cell–mediated rejection (TCMR) develops after alloantigen-primed T cells migrate into an allograft to cause tissue damage. In contrast to antibody-mediated rejection, which creates lesions in the graft vasculature, injury to the graft vasculature is often limited during TCMR. In this issue of the JCI, Barba et al. investigated the mechanism by which the endothelium is spared from harm caused by graft-infiltrating CD8+ T cells.

CONFLICT OF INTEREST STATEMENT BioMerieux funded the study and performed the TTV DNAemia quantification blindly. BioMerieux was not involved in study design, collection and analysis of data, nor in the writing and decision to submit the paper for publication. The remaining authors declare no conflict of interest. Supporting Information Filename Description jmv29806-sup-0001-Chauvelot_Barba_et_al-Revised2-Supplemental_Figure_1.tif33.2 MB Supporting information.