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Thomas Barthlott

As seen in: Science Magazine, BioRxiv
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Articles

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging

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By Xin Yang, Jiaming Cao, Holly V. Moeller, Irene Calvo-Asensio, Fatima Dhalla, Thomas Barthlott, Georg A. Holländer, Michael Morgan, Andreas Tarcevski, Anja Kusch, Saulius Zuklys
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments.
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Thymic epithelial organoids mediate T cell development

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By Tania Hübscher, Francisco Lorenzo-Martin, Thomas Barthlott, Lucie Tillard
| BioRxiv
Abstract Although the advent of organoids opened unprecedented perspectives for basic and translational research, immune system-related organoids remain largely underdeveloped. Here we established organoids from the thymus, the lymphoid organ responsible for T cell development. We identified conditions enabling thymic epithelial progenitor cell proliferation and development into organoids with in vivo-like transcriptional profiles and diverse cell populations.
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