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Articles by Thomas G. Fai
Curvature-based machine learning method for automated segmentation of dendritic spines
Recent advances in connectomics have been led by high-resolution reconstruction of large volumes of neural tissues using electron microscopy (EM), providing unprecedented insights into brain structure and function. Dendritic spines—dynamic protrusions on neuronal dendrites—play crucial roles in synaptic plasticity, influencing learning, memory, and various neurological disorders.
Influence of the vessel wall geometry on the wall-induced migration of red blood cells
Cell-free layer estimation for healthy and disrupted ESL Under different pathological conditions, changes in the ESL can lead to drastic changes in the vessel wall geometry. For instance, under infection or septic conditions, damage of the ESL occurs, enabling leukocyte and platelet adhesion. As a result, the vessel wall thickens and becomes bumpier, disrupting the microcirculation [43, 66].
Passive endocytosis in protocells enables nutrient transport bypassing permeability limits
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Dynamics of Growth and Form in Prebiotic Vesicles
Abstract The growth, form, and division of prebiotic vesicles, membraneous bags of fluid of varying components and shapes is hypothesized to have served as the substrate for the origin of life. The dynamics of these out-of-equilibrium structures is controlled by physicochemical processes that include the intercalation of amphiphiles into the membrane, fluid flow across the membrane, and elastic deformations of the membrane.
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