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Thomas J. Baric

As seen in: Cell Press
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Articles

Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies

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By Emily N. Gallichotte, Ellen Young, Thomas J. Baric
| asm.org
Observation | Host-Microbe Biology Emily N. Gallichotte, Ellen F. Young, Thomas J. Baric, Boyd L. Yount, Stefan W. Metz, Matthew C. Begley, Aravinda M. de Silva, Ralph S. Baric J. S. Malik Peiris, Editor DOI: 10.1128/mBio.01485-19 ABSTRACT Zika virus (ZIKV) is a flavivirus that is structurally highly similar to the related viruses, dengue virus (DENV), West Nile virus, and yellow fever virus.
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Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization

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By Emily N. Gallichotte, Thomas J. Baric, Usha Nivarthi, Matthew J. Delacruz
| Cell Press Verified
There is amino acid variability within the envelope protein across DENV4 genotypes There are four distinct DENV serotypes, and within DENV4, there are five distinct genotypes. The impact of genotypic diversity is not known, nor is it clear whether infection with one DENV4 genotype results in protective immunity against the other genotypes. To measure the impact of DENV4 genetic diversity, we generated an isogenic panel of viruses containing the envelope protein from the different genotypes.
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