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Articles

Functional microRNA targeting without seed pairing

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By Matthew Hall, Peter Wang, Thy Pham, David Bartel
| BioRxiv
Abstract MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to serve as guides, directing binding to partially complementary sites in mRNAs, ultimately causing post-transcriptional repression. Complementarity to the miRNA seed region (miRNA nucleotides 2–7) is typically both necessary and sufficient for repression. Here, we investigate unusual sites with extensive complementarity to the miRNA 3′ region (nucleotide 9 and onwards) but without complementarity to the seed.
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The biochemical basis of microRNA targeting efficacy

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By Sean E. McGeary, Kathy S. Lin, Charlie Y. Shi, Thy Pham
| Science Magazine Verified
MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in which the miRNA recognizes mRNA targets, primarily through pairing to sites that match its extended seed region (miRNA nucleotides 1 to 8) while the AGO protein recruits factors that promote destabilization and translational repression of bound targets.
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The biochemical basis of microRNA targeting efficacy

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By Sean E. McGeary, Charlie Y. Shi, Thy Pham, Kathy S. Lin
| Science Magazine Verified
Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
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