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David Bartel on Muck Rack

David Bartel

Salem
As seen in: Nature, PNAS, Genome Biology, Science Magazine, BioRxiv, Cell Press, Riverside-Brookfield Landmark
My passions: Advancing my knowledge and advancing others. Movies, Video Games, TV Shows, Entertainment in general through a critical lens.

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Articles

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation

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By Jakob Farnung, Elena Slobodyanyuk, Peter Wang, Lianne W. Blodgett, Daniel Lin, Susanne von Gronau, Brenda A. Schulman, David Bartel
| Nature Verified
Abstract MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that down-regulate target RNAs, including messenger RNAs from most human genes1,2,3. Within each complex, the miRNA pairs to target RNAs, and AGO provides effector function while also protecting the miRNA from cellular nucleases2,3,4,5. Although much is known about miRNA-directed gene regulation, less is known about how miRNAs themselves are regulated.
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The G3BP stress-granule proteins reinforce the integrated stress response translation programme - Nature Cell Biology

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By Jarrett Smith, David Bartel
| Nature Verified
Abstract When mammalian cells are exposed to stress, they co-ordinate the condensation of stress granules (SGs) through the action of proteins G3BP1 and G3BP2 (G3BPs) and, simultaneously, undergo a massive reduction in translation. Although SGs and G3BPs have been linked to this translation response, their overall impact has been unclear. Here we investigate the question of how, and indeed whether, G3BPs and SGs shape the stress translation response.
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PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility - Nature Communications

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By Kehui Xiang, David Bartel
| Nature Verified
Abstract In oocytes of mammals and other animals, gene regulation is mediated primarily through changes in poly(A)-tail length. Here, we introduce PAL-AI, an integrated neural network machine-learning model that accurately predicts tail-length changes in maturing oocytes of frogs and mammals.
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