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Tim Rasmussen

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Live review: Neil Young, Neville Brothers, Everest @ Magness Arena " Reverb

Live review: Neil Young, Neville Brothers, Everest @ Magness Arena " Reverb

Neil Young, seen here playing Magness Arena on Monday, is like a good wine. He gets better with age, and the …

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Articles

The gene-regulating proteins NONO and SFPQ assemble into ordered filaments - Communications Biology

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By Tim Rasmussen
| Nature Verified
Abstract Proteins of the Drosophila behaviour/human splicing (DBHS) family are involved in many aspects of gene regulation and maintenance like transcription, splicing and DNA repair. DBHS proteins form obligate homo- and heterodimers through interactions within a globular domain and can further dynamically oligomerise through α-helical coiled-coils, which is crucial for many functions. While the atomic structures of the dimers are established, the arrangement in higher oligomers is unknown.
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Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores - Nature Communications

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By Tim Rasmussen
| Nature Verified
Abstract Osmotically varying environments are challenging for bacterial cells. Sudden drops in osmolytes cause an increased membrane tension and rupture the cells in the absence of protective mechanisms. One family of protective proteins are mechanosensitive channels of small conductance that open in response to membrane tension. Although these channels have a common architecture, they vary widely in the number of transmembrane helices, conductivity, and gating characteristics.
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Structure of lymphostatin, a large multi-functional virulence factor of pathogenic Escherichia coli - Nature Communications

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By Matthias Griessmann, Tim Rasmussen, Ronja Schneider, Lukas Spantzel, Michael Börsch
| Nature Verified
Abstract Lymphostatin is a key virulence factor of enteropathogenic and enterohaemorrhagic Escherichia coli, playing roles in bacterial colonisation of the gut and in the inhibition of lymphocyte proliferation and proinflammatory responses. The protein’s glycosyltransferase and cysteine protease motifs are required for activity against lymphocytes, but high-resolution structural information has proven elusive. Here, we describe the structure of lymphostatin from enteropathogenic E.
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