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Articles by Tim Veth
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Abstract Despite the curative potential of checkpoint blockade immunotherapy, many patients remain unresponsive to existing treatments. Glyco-immune checkpoints, which involve interactions of cell-surface glycans with lectin, or glycan-binding, immunoreceptors, have emerged as prominent mechanisms of immune evasion and therapeutic resistance in cancer. Here, we describe antibody-lectin chimeras (AbLecs), a modular system for glyco-immune checkpoint blockade.
Sialoglycans on human T cells attenuate death programs executed through the Fas pathway
Keywords T cells apoptosis immunology glycobiology glycosyltransferase sialic acid Abbreviations—The abbreviations used are ST6GAL1 (ST6 beta-galactosidase alpha-2,6-sialyltransferase 1) WT (wild type) -/- (homozygous knock out) SNA (Sambucus nigra lectin) ECL (Erythina cristagalli lectin) FMO (fluorescence minus one) FasR (Fas receptor) FasL (Fas ligand) TNFα (tumour necrosis factor alpha) TNFR1 (tumour necrosis factor receptor 1) TRAIL-R1 (TRAIL receptor 1) TRAIL (TNF-related...
Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference - Nature Communications
Abstract A critical step in infections is the attachment of microorganisms to host cells using lectins that bind glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, an adhesin in E. coli, undergoes an allosteric transition from an inactive to an active conformation that can act as a catch-bond. Distinct monoclonal antibodies that alter FimH glycan binding are available, but the mechanisms of action remain unclear.
Accelerating the stride toward functional glycoproteomics
Get full text access Log in, subscribe or purchase for full access. References 1. Varki, A. Biological roles of glycans Glycobiology. 2017; 27:3-49 2. Bagdonaite, I. ... Glycoproteomics Nat. Rev. Methods Primers. 2022; 2:1-29 3. Potel, C.M. ... Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco) Nat. Struct. Mol. Biol. 2025; 4. Riley, N.M. ... Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis Nat. Commun. 2019; 10:1311 5.
Autonomous Dissociation-type Selection for Glycoproteomics Using a Real-Time Library Search
Introduction Click to copy section linkSection link copied! Protein glycosylation is a highly heterogeneous collection of co- and post-translational modifications.
Autonomous Dissociation-type Selection for Glycoproteomics Using a Real-Time Library Search
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CD5L is a canonical component of circulatory IgM
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Elucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling
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Optimized Suspension Trapping Method for Phosphoproteomics Sample Preparation
A successful mass spectrometry-based phosphoproteomics analysis relies on effective sample preparation strategies. Suspension trapping (S-Trap) is a novel, rapid, and universal method of sample preparation that is increasingly applied in bottom-up proteomics studies. However, the performance of the S-Trap protocol for phosphoproteomics studies is unclear.
Temporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons
Temporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons Charlotte AGH van Gelder, Renske Penning, Tim Veth, Lisa AE Catsburg, Casper C. Hoogenraad, Harold D MacGillavry, Maarten Altelaar Molecular & Cellular Proteomics September 10, 2020, mcp.RA120.002199; DOI: 10.1074/mcp.RA120.002199
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