Timaeus EF Morgan on Muck Rack

Timaeus EF Morgan

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[18F]LW223 has low non-displaceable binding in murine brain, enabling high sensitivity TSPO PET imaging

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By Mark Macaskill, Agne Knyzeliene, Carlos J Alcaide-Corral, Timaeus EF Morgan
| SAGE Publishing
Introduction The 18 kDa translocator protein (TSPO), is a multifunctional protein expressed in the outer mitochondrial membrane, which plays a role in steroidogenesis, energy metabolism, cell proliferation, apoptosis and immunomodulation.1,2 TSPO is also a biomarker of neuroinflammation, as its expression in the brain is upregulated under inflammatory conditions.3 Positron emission tomography (PET) imaging of TSPO has been used for non-invasive assessment of neuroinflammation in a number of...
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