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Timothy Bo Yuan on Muck Rack

Timothy Bo Yuan

As seen in: BioRxiv, The Journal of Clinical Investigation
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Articles

Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice

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By Bichen Zhang, Morgan Johnson Verified, Timothy Bo Yuan, Tammy-Nhu Nguyen
| The Journal of Clinical Investigation
Abstract Glycogenolysis and gluconeogenesis ensure sufficient hepatic glucose production during energy shortages. Here, we report that hepatic glycogen levels control the phosphorylation of a transcriptional coactivator to determine the amplitude of gluconeogenesis. Decreased liver glycogen during fasting promotes gluconeogenic gene expression, while feeding-induced glycogen accumulation suppresses it.
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Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis

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By Lauren E Fries, Allen Chung, Hyun-Kyung Chang, Timothy Bo Yuan
| BioRxiv
Abstract Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the western world despite the success of lipid lowering therapies, highlighting the need for novel lipid-independent therapeutic strategies.
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Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis

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By Lauren E Fries, Allen Chung, Timothy Bo Yuan, Hyun-Kyung Chang
| BioRxiv
Abstract Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality in the western world, despite great successes with lipid lowering therapies. This alarming trend highlights the need for novel lipid-independent therapeutic strategies for the treatment of ASCVD.
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