Timsse Raj

1 Introduction NF-κB constitutes a family of transcription factors that critically controls immune homeostasis. Thus, mutations and aberrations within the NF-κB signaling pathway are associated with various autoinflammatory and autoimmune diseases [1-3]. As NF-κB controls multiple functions, including survival, proliferation, differentiation, and activation of immune cells, its activity and effects on target gene expression have to be tightly controlled.

Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated in response to T cell receptor (TCR) and Ca2+ signals. Downregulation requires Stim1/Stim2 and CaMK4 expression and involves Arpp21 protein phosphorylation, polyubiquitination and proteasomal degradation.