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Yinhu Wang

As seen in: Nature
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Correction to “The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression” | Nature Communications

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By Taku Ito-Kureha, Hyun-Seo Kang, Timsse Raj, Florian Giesert, Yinhu Wang, Tobias Straub, Regina Feederle, Carolin Daniel, Julian König, George C Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-46371-z, published online 11 March 2024 The original version of this Article contained errors in Fig. 6, in which the panel labels were misplaced, causing mismatches between the panels and legend. This has been corrected in both the PDF and HTML versions of the Article.
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The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression - Nature Communications

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By Taku Ito-Kureha, Hyun-Seo Kang, Timsse Raj, Florian Giesert, Tobias Straub, Regina Feederle, Carolin Daniel, Julian König, George C Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Yinhu Wang
| Nature Verified
Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated in response to T cell receptor (TCR) and Ca2+ signals. Downregulation requires Stim1/Stim2 and CaMK4 expression and involves Arpp21 protein phosphorylation, polyubiquitination and proteasomal degradation.
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