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Tin Ho Yuen on Muck Rack

Tin Ho Yuen

As seen in: The Journal of Clinical Investigation
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Articles

CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice

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By JCI Insight, Haoyu Deng, Le Chen, Tin Ho Yuen
| The Journal of Clinical Investigation
Abstract Sepsis is a leading cause of mortality worldwide, and pneumonia is the most common cause of sepsis in humans. Low levels of high-density lipoprotein cholesterol (HDL-C) levels are associated with an increased risk of death from sepsis, and increasing levels of HDL-C by inhibition of cholesteryl ester transfer protein (CETP) decreases mortality from intraabdominal polymicrobial sepsis in APOE*3-Leiden.CETP mice.
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