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Tingkai Zhong

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Articles

Thromboxane A2 receptor signalling amplifies osteoclastogenesis in rheumatoid arthritis through ACSL1 associated mitochondrial oxidative metabolism

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By Liyan Mei, Xin Li Verified, Siyuan Rao, Zifeng Chen, Chenguang Zhan, Xingrui Yan, Mengyang Ma, Peng Zhang, Yu Ho Wen, Xiang Guo, Meiqi Chen, Xiaodong Wu, Kaixin Gao, Haifang Du, Huimin Wang, He Baltimore Sun, Xiumin Chen, Boudewijn M. T. Burgering, Maojie Wang, Runyue Huang, Chunping Bo, Chuangning Li, Bozheng Chen, Junao Wang, Tingkai Zhong, Shuxu Wu
| Nature Verified
Abstract Activated platelets contribute to inflammation in rheumatoid arthritis, but how platelet-derived signals promote bone erosion remains poorly understood. Here we show that thromboxane A2, a major mediator released by activated platelets, promotes the formation of bone-resorbing osteoclasts through the thromboxane A2 receptor.
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