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Tisham De

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Articles

Predicting trajectories of illness using RNA velocity of whole blood

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By Claire Dunican, Clare Wilson Verified, Dominic Habgood-Coote, Mahdad Noursadeghi, Cari Stek, Robert Wilkinson, Philipp Agyeman, Giske Biesbroek, Ulrich von Both, Enitan D. Carrol, Giselle D’Souza, Tisham De, Marieke Emonts, Katy Fidler, Colin Fink, Laura Kolberg, Taco W. Kuijpers, Federico Martinón-Torres, Samuel Nichols, Stephane Paulus, Marko Pokorn, Andrew Pollard Verified, Irene Rivero-Calle, Luregn J. Schlapbach, Nina Schweintzger, Ching-Fen Shen, Shrijana Shrestha, Chantal D Tan, Maria Tsolia, Effua Abigail Usuf, Clementien L Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Victoria Wright, Michael Levin, Jethro A. Herberg, Rachel Lai, Graeme Meintjes, Christopher J Chiu, Mauricio Barahona, Myrsini Kaforou, Aubrey J Cunnington, Suzanna Paterson, Raymond Moseki, Coco R. Beudeker, Karen Brengel-Pesce, Lachlan J. M. Coin, Michiel van der Flier, Ioanna Georgaki, Mojca Kolnik, Marine Mommert-Tripon, Aleksandra Rudzate, Fabian van der Velden, Marie Voice
| Nature Verified
Abstract Transcriptomic analyses reveal the status of cells, tissues, or organisms, across states of health and disease. RNA velocity adds a temporal dimension to single cell analyses, predicting future transcriptomic and phenotypic states, based on the current spliced and unspliced mRNA of each cell. We hypothesized that RNA velocity could be adapted to predict future clinical state of individuals with acute and chronic illnesses, using their whole-blood transcriptomes.
Open in Who Shared Issue with article?

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children - Nature Communications

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By Michael Carter, Heather Jackson, Nedyalko Petrov, Paul Wellman, Jonathan Cohen, Samuel Nichols, Victoria Wright, Dominic Habgood-Coote, Pierre Tissieres, Aubrey J Cunnington, Myrsini Kaforou, Richard Ellis, Michael H. Malim, Manu Shankar-Hari, Michael Levin, Francesca Davis, Tisham De
| Nature Verified
Abstract Severe febrile illnesses in children encompass life-threatening organ dysfunction caused by diverse pathogens and other severe inflammatory syndromes. A comparative approach to these illnesses may identify shared and distinct features of host immune dysfunction amenable to immunomodulation.
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