Tlili Barhoumi

Abstract The gut microbiota has emerged as a potential biomarker in the pathogenesis of colorectal cancer (CRC). Although several studies across diverse populations have identified CRC-associated microbial signatures, evidence from the Saudi Arabian population remains scarce. In this case–control study, we profiled and compared the fecal microbiotas of Saudi patients with CRC (n = 52) with those of two control groups: healthy relatives (n = 38) and an independent healthy cohort (n = 37).

Background: Platelet concentrates (PCs) are vital for treating hematologic disorders and thrombocytopenia, yet their short shelf life (3–5 days) is limited by platelet storage lesion (PSL)-a process involving biochemical and structural deterioration that reduces post-transfusion efficacy. This study aimed to characterize alterations in platelet surface receptors and RNA content during storage to better understand PSL mechanisms.

Introduction Cardiovascular diseases (CVDs) are a leading cause of death globally, accounting for nearly 32% of all deaths in 2019 (1). Despite the impact of the COVID-19 pandemic, recent studies demonstrate that cardiovascular mortality remained the leading cause of death (2, 3). Notably, the World Health Organization (WHO) predicts that the mortality rate from CVDs will increase from 246 to 264 people per 100,000 during the period 2015–2030 (4–6).