Although the incidence of multisystem inflammatory syndrome in children (MIS-C) has decreased since the height of the COVID-19 pandemic, some cases still occur, particularly in unvaccinated and partially vaccinated populations, according to study findings published in Clinical Infectious Diseases. Early in the pandemic, MIS-C emerged as a complication of SARS-CoV-2 infection, with the US Centers for Disease Control and Prevention (CDC) initiating national surveillance in May 2020.