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Keywords KMT2A::AFF1 acute lymphoblastic leukemia central nervous system immune microenvironment microRNA miR-93 infant leukemia PTEN leptomeninges immune suppression Research topic(s) CP: immunology CP: cancer Introduction Acute lymphoblastic leukemia (ALL) involvement of the central nervous system (CNS) is the most common and most clinically significant extra-medullary site of disease across all age groups.
Abstract Systemic inflammation can lead to neuroinflammation with acute consequences such as delirium and long-lasting deleterious effects including cognitive decline and the exacerbation of neurodegenerative disease progression. Here we show that the activation status of the transcription factor Nrf2 in endothelial cells is a critical regulator of this process.
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