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Tomoya Muto

As seen in: Nature, Cell Press, Cell Stem Cell
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Articles by Tomoya Muto

TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity

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By Tomoya Muto, Maria Guillamot, Jennifer Yeung, Jing Fang
| Cell Stem Cell Verified
Ågerstam H. Karlsson C. Hansen N. Sandén C. Askmyr M. von Palffy S. Högberg C. Rissler M. Wunderlich M. Juliusson G. et al. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia. Proc. Natl. Acad. Sci. USA. 2015; 112: 10786-10791 Alexandrov L.B. Nik-Zainal S. Wedge D.C. Aparicio S.A. Behjati S. Biankin A.V. Bignell G.R. Bolli N. Borg A. Børresen-Dale A.L. et al. Signatures of mutational processes in human cancer. Nature. 2013; 500: 415-421 Aran D.
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Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

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By Averil Ma, Tomoya Muto, Callum Walker, Daniel T. Starczynowski
| Nature Verified
Abstract Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and progenitor cells (HSPCs), the mechanisms responsible for the competitive advantage of MDS HSPCs in an inflammatory milieu over normal HSPCs remain poorly defined. Here, we found that chronic inflammation was a determinant for the competitive advantage of MDS HSPCs and for disease progression.
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TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

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By Jing Fang, Maria Kleppe, Lyndsey C Bolanos, Tomoya Muto
| Cell Press Verified
Deletion of Traf6 in Hematopoietic Cells Leads to Premature Lethality and Hematologic Defects   Deletion of Traf6 Leads to Loss of HSPC   IKK? Deficiency Leads to Loss of HSPC and Impaired Hematopoietic Reconstitution To evaluate the self-renewal potential of Traf6-deficient HSC, we performed competitive BM transplantation assays.
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