Belzutifan (Welireg), a HIF-2α inhibitor, combined with lenvatinib (Lenvima) yielded superior progression-free survival (PFS) and objective response rate (ORR) compared with cabozantinib (Cabometyx) in patients with advanced clear cell renal cell carcinoma (ccRCC) after immune checkpoint inhibitor therapy, according to results from the LITESPARK-011 trial (NCT04586231) presented by Robert J. Motzer, MD, at the 2026 ASCO Genitourinary Cancers Symposium.