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Toufigh Gordi on Muck Rack

Toufigh Gordi

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Preclinical characterization and early development of R835, a novel, selective dual IRAK1 and IRAK4 inhibitor

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By Simon Shaw, Chrystelle Lamagna, Lucy Yan, Sylvia Braselmann, Esteban S Masuda, Vadim Markovtsov, Toufigh Gordi
| Nature Verified
Abstract Interleukin-1 receptor associated kinase (IRAK)1 and IRAK4 are serine/threonine kinases critical for downstream signaling of most toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs), leading to proinflammatory cytokine production and activation of innate immune and inflammatory responses.
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