Trevor Nash

Graphical Abstract Human Organ-on-Chip Platform This cover displays an astronaut holding an organ-on-a-chip model of heart, liver, and bone marrow tissues linked by vascular flow. This graphical representation illustrates the capability of organ-on-achip models to conduct individualized studies of the effects of space stressors on human/astronaut health. More details can be found in article number 2401415 by Daniel Naveed Tavakol, Gordana Vunjak-Novakovic, and co-workers.

Abstract Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms of myocardial injury in SLE remain poorly understood. In this study, we engineered human cardiac tissues and cultured them with IgG from patients with SLE, with and without myocardial involvement.

Muchtar E. Blauwet L.A. Gertz M.A. Restrictive cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy. Circ. Res. 2017; 121: 819-837https://doi.org/10.1161/CIRCRESAHA.117.310982 Felker G.M. Thompson R.E. Hare J.M. Hruban R.H. Clemetson D.E. Howard D.L. Baughman K.L. Kasper E.K. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N. Engl. J. Med.