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TriLab Bioinformatics Group

As seen in: PLOS, Cell Reports
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Articles

Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species

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By Hernan A. Lorenzi, TriLab Bioinformatics Group, Kidney Diseases, Clio Hockens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Hockens C, Lorenzi H, Wang TT, Lei EP, Rosin LF (2024) Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species. PLoS Genet 20(6): e1011329. https://doi.org/10.1371/journal.pgen.1011329 Editor: R.
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Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response

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By Agnes Karasik, Kidney Diseases, Hernan A. Lorenzi, TriLab Bioinformatics Group
| Cell Reports Verified
Highlights • Activated RNase L acts with dsRNA-sensing pathways to promote cell signaling • RNA fragmentation induces transcription through ZAKα signaling • Activation of RNase L modulates levels of eIF2α phosphorylation • Translation of stress-responsive mRNAs is inhibited by active RNase L Summary Viral infection triggers several double-stranded RNA (dsRNA) sensors that lead to changes in gene expression in the cell.
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