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Tsai-Lien Liao on Muck Rack

Tsai-Lien Liao

As seen in: Journal of Biomedical Science
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Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE−/− mice fed high fat diet - Journal of Biomedical Science

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By Guan-Lin Lee, Jing-Yiing Wu, Kenneth K. Wu, Cheng-Chin Kuo, Tsai-Lien Liao
| Journal of Biomedical Science Verified
Abstract Background Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly identified factor with anti-inflammatory actions. As 5-MTP targets p38 MAPK for its actions, we postulated that 5-MTP protects against vascular chondrogenesis and calcification.
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