Tsoi Ying Lai on Muck Rack

Tsoi Ying Lai

As seen in: Microbiology Research
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Articles

SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS–STING

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By Hsin-Ping Chiu, Yao Yu Yeo, Tsoi Ying Lai
| Microbiology Research
Article metrics loading... /content/journal/jgv/10.1099/jgv.0.002233 Metrics Download as PowerPoint /deliver/fulltext/jgv/107/3/jgv002233.html?itemId=/content/journal/jgv/10.1099/jgv.0.002233&mimeType=html&fmt=ahah References V’kovski P, Kratzel A, Steiner S, Stalder H, Thiel V. Coronavirus biology and replication: implications for SARS-CoV-2. Nat Rev Microbiol 2021; 19:155–170 [View Article] [PubMed] [Google Scholar] Deng X, Baker SC.
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SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses

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By Benhur Lee, Yao Yu Yeo, Hsin-Ping Chiu, Tsoi Ying Lai
| biorxiv.org
Abstract Coronavirus (CoV) Nsp15 is a viral endoribonuclease (EndoU) with a preference for uridine residues. CoV Nsp15 is an innate immune antagonist which prevents dsRNA sensor recognition and stress granule formation by targeting viral and host RNAs. SARS-CoV-2 restricts and delays the host antiviral innate immune responses through multiple viral proteins, but the role of SARS-CoV-2 Nsp15 in innate immune evasion is not completely understood.
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