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Tsutomu Matsubara on Muck Rack

Tsutomu Matsubara

As seen in: Nature, Wiley Online Library, MDPI, Science Magazine, Royal Society of Chemistry, The Journal of Biological Chemistry
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Articles

Microtubule-Targeting Drugs Induce Mesenchymal–Epithelial Transition in Hepatic Stellate Cells

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By Hayato Urushima, Tsutomu Matsubara, Hideto Yuasa
| Wiley Online Library Verified
1 Background Liver cirrhosis, the end stage of liver fibrosis, is a fatal disease with a poor prognosis. It is characterized by a significant decline in liver functions such as albumin production, metabolism, and bile acid excretion, and it serves as a major risk factor for liver cancer [1]. Pathologically, liver fibrosis is defined by the excessive accumulation of extracellular matrix components in the space of Disse.
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Liver-derived Neuregulin1α stimulates compensatory pancreatic β cell hyperplasia in insulin resistance - Nature Communications

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By Takatomo Arai, Tsutomu Matsubara, Sadatomo Wainai, Minami Yoshikai, Masayuki Shimoda, Minoru Tanaka, Norifumi Kawada
| Nature Verified
Abstract Compensatory pancreatic islet hyperplasia is an adaptive response to increased systemic insulin demand, although factors meditating this response remain poorly understood. Here, we show that a liver-derived secreted protein, Neuregulin1α, promotes compensatory proliferation of pancreatic β cells in type 2 diabetes. Liver Neuregulin1α expression and serum Neuregulin1α levels increase in male mice fed an obesity-inducing diet.
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Application of PPAR Ligands and Nanoparticle Technology in Metabolic Steatohepatitis Treatment

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By Vien Nguyen, Hiroko Ikenaga, Tsutomu Matsubara, Hung Thai Vu
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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