Tsveta S. Malinova

Nanoparticles can affect vascular integrity, promoting cancer cell intravasation and extravasation and metastasis in murine breast cancer models. Access optionsAccess options Subscribe to Journal Get full journal access for 1 year $187.00 only $15.58 per issue All prices are NET prices. VAT will be added later in the checkout. Rent or Buy article Get time limited or full article access on ReadCube. from$8.99 All prices are NET prices. References 1. Peng, F. et al. Nat. Nanotechnol.

AJs are mechanosensitive structures that propagate force-induced signals across cell moieties. Collective cell migration is linked to cytoskeletal dynamics, leading to front–rear cell polarization. In a cell collective, front–rear cell polarization promotes lateral and transverse junctional asymmetry.

The F-BAR protein pacsin2 (also known as syndapin2) is known to regulate the actin cytoskeleton31, 32, 33 and endocytosis30, 34. While studying the role of pacsin2 in cytoskeletal remodelling during spreading of primary human umbilical vein endothelial cells (HUVECs)33, we observed that a subset of pacsin2 protein localizes near cell–cell junctions. This suggested that this F-BAR protein is involved in junction regulation.