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Tsz Lok Wong

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Articles

Tethered agonist– and GAIN domain–independent signaling of an adhesion GPCR

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By Yu Sun, Jie Wang, Haoyu Hu, Yi Miao, Jinzhao Wang, Yu ZHANG, Ahmed Yousif, Marius Wernig, Thomas C. Südhof, Shaoyuan Zhu, Tsz Lok Wong
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In transfected cells, adhesion G protein–coupled receptors (GPCRs) are activated by tethered agonists that are embedded in their canonical autoproteolytic GAIN domain.
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